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  • br Molecular properties that influence the oral bioavailabil

    2019-09-23


    Molecular properties that influence the oral bioavailability of drug candidates. J.
    Available online at www.sciencedirect.com
    ScienceDirect
    ORIGINAL ARTICLE
    5-year oncological outcomes of targeted axillary sampling in pT1-2N1 breast cancer
    Jeeyeon Lee a, Jin Hyang Jung a, Wan Wook Kim a, Ryu Kyung Lee a, Hye Jung Kim b, Won Hwa Kim b,
    Ji-Young Park c, Ji-Yun Jeong c, Yee Soo Chae d, Soo Jung Lee d, Shin-Hyung Park e, Mi Young Kim e, Jung Dug Yang f, Jeong Woo Lee f, Joon Seok Lee f, Ho Yong Park a,*
    a Department of Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea
    b Department of Radiology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea
    c Department of Pathology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea
    d Department of Hemato-Oncology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea
    e Department of Radiation Oncology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea
    f Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea
    Available online 22 November 2018
    KEYWORDS
    Breast;
    Carcinoma;
    Lymph node;
    Dissection;
    Sampling 
    Summary Background: axillary M3814 (nedisertib) nodes dissection (ALND) has been a standard treat-ment in breast cancer with positive sentinel LNs. However, various short- and long-term post-operative morbidities have been reported after conventional ALND. To define the concept of targeted axillary sampling (AS) and to assess its oncological feasibility for breast cancer. We compared the oncological outcomes in the axillary area between conventional ALND and tar-geted AS with or without radiotherapy.
    Methods: One hundred and twenty-nine female patients with cT1-2N1 breast cancer under-went breast and axillary surgery. We defined the concept of targeted AS in clinical and path-ological terms, and the oncological outcomes were compared between ALND and AS, and between AS with and without radiotherapy.
    * Corresponding author. Department of Surgery, School of Medicine, Kyungpook National University, Hoguk-ro 807, Buk-gu, Daegu, 41404,
    1015-9584/ª 2018 Asian Surgical Association and Taiwan Robotic Surgery Association. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
    Results: There were no significant differences in oncological outcomes in the axilla between conventional ALND and AS, or between AS with radiotherapy and AS alone.
    Conclusions: The 5-year oncological outcomes of targeted AS were not inferior to those of con-ventional ALND, regardless of whether radiotherapy was added.
    ª 2018 Asian Surgical Association and Taiwan Robotic Surgery Association. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
    1. Introduction
    Axillary lymph node (ALN) status has strong prognostic value in breast cancer and is a key factor in the TNM staging system for breast cancer. Theoretically, the most accurate method to evaluate the status of ALN metastasis and calculate the tumor burden of breast cancer would be to remove all of the visible ALNs. However, this method may lead to high morbidity, including axillary pain and limitation of arm movements, and numbness and lymphedema as long-term complications that disrupt quality of life.1e3