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  • SCR7 br Dynamic nuclear magnetic resonance morphological cha

    2020-08-12


    Dynamic nuclear magnetic resonance morphological changes
    In the dynamic enhancement sequence, the most obvious axial plane is used as the longest diameter of the tumor. If multiple lesions or multi-center lesions are used, the sum of the longest diameters of each lesion is taken as the longest diameter of the tumor (the lesion with the longest diameter not exceeding 0.1 cm is not counted). Evaluation is carried out according to the solid tumor evaluation criteria (RECIST). CR: all lesions disappear. PR: baseline lesions total diameter reduction ratio is greater than 30%. SD: base-line lesion long diameter sum reduction is between PR and PD. PD is the total length of the basel.
    Semi-quantitative analysis of dynamic enhanced magnetic resonance imaging for comparison of lesion TIC types
    Time zone intensity cbrve (TIC) of dynamic enhanced magnetic resonance imaging is drawn by selecting at least 3 regions of inter-est for each lesion, measuring its signal value and calculating the mean value. According to the morphological results of the time sig-nal intensity curve, the lesions are typed according to the following criteria. Type I (sustained type): the signal intensity continues to increase during the dynamic observation time. Type II (platform type): the early signal intensity continues to increase. The signal intensity is interrupted to form a platform in the middle and late stage. Type III (outflow type): the early signal intensity gradually increases, and then the signal intensity gradually decreases.
    Please cite this article in press as: Yang C, Zhao H. Application of dynamic magnetic resonance imaging information technology in adjuvant chemotherapy for breast cancer. J Infect Public Health (2019), https://doi.org/10.1016/j.jiph.2019.06.020
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    Fig. 1. Breast cancer HE staining pathological changes assessment results.
    Calculation of quantitative analysis parameters of dynamic enhanced magnetic resonance imaging
    There are four commonly used quantitative parameters for dynamic enhanced magnetic resonance imaging. Ktrans : volume transfer constant refers to the rate at which the SCR7 agent transfers from the intravascular to extravascular extracellular
    space. Kep : rate constant refers to the rate at which the contrast agent flows back into the blood vessel from the extravascular extra-cellular space. Ve : the volume of extracellular space per unit volume of tissue refers to the extravascular space of the extravascular space per unit volume of tissue capacity. Vp : the volume fraction of plasma refers to the intravascular volume of contrast agent as a percentage of the volume of the entire voxel.
    Please cite this article in press as: Yang C, Zhao H. Application of dynamic magnetic resonance imaging information technology in adjuvant chemotherapy for breast cancer. J Infect Public Health (2019), https://doi.org/10.1016/j.jiph.2019.06.020
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    Table 2
    Results of tumor morphological changes before and after neoadjuvant chemotherapy.
    RECIST Number of cases
    Table 3
    TIC type conversion results before and after neoadjuvant chemotherapy.
    TIC type Number of cases
    Quantitative analysis of DCE-MRI can accurately reflect the changes of tissue microenvironment system and the pathophys-iological changes of the lesions, which plays an important role in the diagnosis of tumors. It can judge the nature of the lesion. Among them, Ktrans and Kep can reflect the number of microvessels and the amount of blood perfusion in breast cancer lesions, while the val-ues of Ve and Vp reflect the matrix components and edema of the tumor.
    Statistical method
    Data processing and analysis are performed by SPSS21.0 statisti-cal software. Quantitative data consistent with normal distribution are described by mean ± standard deviation. Comparison between the two groups is performed by two independent samples t test or rank sum test. The comparison of different group rates is performed by chi-square test.
    Results and discussion
    HE staining pathological change assessment results
    The results of pathological evaluation of neoadjuvant chemotherapy are used as control standards. The results of the analysis according to the Miller-Payne grading system standard are shown in Table 1, and Fig. 1.
    Dynamic nuclear magnetic resonance morphological change assessment results
    It is assessed that the maximum length of the lesion is 5.35 ± 1.95 cm before neoadjuvant chemotherapy, and the longest diameter is 3.01 ± 1.13 cm after neoadjuvant chemotherapy. The 
    results of the analysis according to the solid tumor evaluation cri-teria (RECIST) are shown in Table 2 and Fig. 2.